The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21.

Authors

• R H Reeves
• M R Crowley
• N Lorenzon
• W J Pavan
• R J Smeyne
• D Goldowitz

Publication/Presentation Date

10-1-1989

Abstract

Utilizing the backcross C57BL/6 wv/wv x (C57BL/6 wv/wv x MOLD/Rk), the mouse neurological mutation weaver (wv) was mapped less than 1 cM proximal to Ets-2 and Mx on mouse chromosome 16 (0.96 +/- 0.1% recombination). This region is known to include eight genes that are found on human chromosome 21 (HSA 21) and appears to be highly conserved between the two species. We therefore predict that the normal human homolog of wv will be located on HSA 21 and would be in dosage imbalance in individuals with Down syndrome.

Volume

5

Issue

3

First Page

522

Last Page

526

ISSN

0888-7543

Published In/Presented At

Reeves, R. H., Crowley, M. R., Lorenzon, N., Pavan, W. J., Smeyne, R. J., & Goldowitz, D. (1989). The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21. Genomics, 5(3), 522–526. https://doi.org/10.1016/0888-7543(89)90018-9

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

2575584

Department(s)

Administration and Leadership

Document Type

Article