Glutathione metabolism and Parkinson's disease.
Publication/Presentation Date
9-1-2013
Abstract
It has been established that oxidative stress, defined as the condition in which the sum of free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the pathogenesis of Parkinson disease. Glutathione is a ubiquitous thiol tripeptide that acts alone or in concert with enzymes within cells to reduce superoxide radicals, hydroxyl radicals, and peroxynitrites. In this review, we examine the synthesis, metabolism, and functional interactions of glutathione and discuss how these relate to the protection of dopaminergic neurons from oxidative damage and its therapeutic potential in Parkinson disease.
Volume
62
First Page
13
Last Page
25
ISSN
1873-4596
Published In/Presented At
Smeyne, M., & Smeyne, R. J. (2013). Glutathione metabolism and Parkinson's disease. Free radical biology & medicine, 62, 13–25. https://doi.org/10.1016/j.freeradbiomed.2013.05.001
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23665395
Department(s)
Administration and Leadership
Document Type
Article