The MPTP model of Parkinson's disease.

Authors

• Richard Jay Smeyne
• Vernice Jackson-Lewis

Publication/Presentation Date

3-24-2005

Abstract

The biochemical and cellular changes that occur following administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic Parkinson's disease (PD). In this review, we detail the molecular activities of this compound from peripheral intoxication through its various biotransformations. In addition, we detail the interplay that occurs between the different cellular compartments (neurons and glia) that eventually consort to kill substantia nigra pars compacta (SNpc) neurons.

Volume

134

Issue

1

First Page

57

Last Page

66

ISSN

0169-328X

Published In/Presented At

Smeyne, R. J., & Jackson-Lewis, V. (2005). The MPTP model of Parkinson's disease. Brain research. Molecular brain research, 134(1), 57–66. https://doi.org/10.1016/j.molbrainres.2004.09.017

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

15790530

Department(s)

Administration and Leadership

Document Type

Article