Parkinsonism and neurological manifestations of influenza throughout the 20th and 21st centuries.
Publication/Presentation Date
11-1-2010
Abstract
PURPOSE: Given the recent paper by Jang et al. on "A Highly Pathogenic H5N1 Influenza Virus" which reported a novel animal model of parkinsonism, we aimed to perform a complete historical review of the 20th and 21st century literature on parkinsonism and neurological manifestations of influenza.
SCOPE: There were at least twelve major flu pandemics reported in the literature in the 20th and 21st century. Neurological manifestations most prevalent during the pandemics included delirium, encephalitis, ocular abnormalities, amyotrophy, myelopathy, radiculopathy, ataxia and seizures. Very little parkinsonism was reported with the exception of the 1917 cases originally described by von Economo.
CONCLUSIONS: To date there have been surprisingly few cases of neurological issues inclusive of parkinsonism associated with influenza pandemics. Given the recent animal model of H5N1 influenza associated parkinsonism, the medical establishment should be prepared to evaluate for the re-emergence of parkinsonism during future outbreaks.
Volume
16
Issue
9
First Page
566
Last Page
571
ISSN
1873-5126
Published In/Presented At
Henry, J., Smeyne, R. J., Jang, H., Miller, B., & Okun, M. S. (2010). Parkinsonism and neurological manifestations of influenza throughout the 20th and 21st centuries. Parkinsonism & related disorders, 16(9), 566–571. https://doi.org/10.1016/j.parkreldis.2010.06.012
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
20650672
Department(s)
Administration and Leadership
Document Type
Article