Caspase-3-dependent neuronal death in the hippocampus following kainic acid treatment.
Publication/Presentation Date
6-18-1999
Abstract
In this study, we examined the levels of activated caspase-3 in the kainic acid (KA) model of hippocampal degeneration in both sensitive (FVB/N) and resistant (129/SvEMS) strains of mice. At 30 h, 2 and 4 days following KA administration, animals were sacrificed and brains examined for pyknosis, TUNEL labeling, and activated caspase-3 immunoreactivity. Catalytically active caspase-3 was first detected 30 h following KA treatment in the sensitive, FVB/N strain. This was 18 h before the appearance of pyknosis or TUNEL labeling. The expression of activated caspase-3 continues up to 4 days post-injection. No activated caspase-3 immunoreactivity was detected in the resistant, 129/SvEMS strain, neither was there evidence of pyknosis or TUNEL staining. This suggests that activation of caspase-3 is a necessary component of KA-induced cell death.
Volume
70
Issue
1
First Page
159
Last Page
163
ISSN
0169-328X
Published In/Presented At
Faherty, C. J., Xanthoudakis, S., & Smeyne, R. J. (1999). Caspase-3-dependent neuronal death in the hippocampus following kainic acid treatment. Brain research. Molecular brain research, 70(1), 159–163. https://doi.org/10.1016/s0169-328x(99)00143-6
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
10381555
Department(s)
Administration and Leadership
Document Type
Article