Transgenic approaches to cerebellar development.
Publication/Presentation Date
1-1-1997
Abstract
The advent of transgenic mouse technology and the harnessing of homologous recombination to eliminate genes in living animals have provided powerful new approaches to investigate some of the fundamental issues in developmental neurobiology. In this chapter we illustrate several examples of the use of these technologies to investigate the murine cerebellum. These range from using inert, marker transgenes to follow the organization strategy of the cerebellum, to eliminating specific cell populations and modifying the function and fate of Purkinje cells. Finally, we provide a perspective on future extensions of these transgenic approaches.
Volume
5
Issue
1
First Page
33
Last Page
41
ISSN
1064-0517
Published In/Presented At
Morgan, J. I., & Smeyne, R. J. (1997). Transgenic approaches to cerebellar development. Perspectives on developmental neurobiology, 5(1), 33–41. https://doi.org/10.1080/0907676x.1997.9961297
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
9509516
Department(s)
Administration and Leadership
Document Type
Article