Immune reactions to P2 protein in human inflammatory demyelinative neuropathies.

Authors

• B Zweiman
• A Rostami
• R P Lisak
• A R Moskovitz
• D E Pleasure

Publication/Presentation Date

2-1-1983

Abstract

The significance of immune reactions against peripheral nervous system antigens in the human inflammatory polyneuropathies is still uncertain. Using a very sensitive assay, we found greatly increased levels of anti-P2 antibodies in sera of animals with experimental allergic neuritis (EAN) but no increases in humans with acute Guillain-Barré syndrome (GBS), chronic relapsing polyneuritis (CRIP), axonal neuropathy, or normals. P2 protein and CNS basic protein did not induce any increased proliferation in lymphocytes of GBS or CRIP patients. We conclude that P2 and BP appear unlikely to be targets for humoral or cellular immune reactivity in GBS or CRIP.

Volume

33

Issue

2

First Page

234

Last Page

237

ISSN

0028-3878

Published In/Presented At

Zweiman, B., Rostami, A., Lisak, R. P., Moskovitz, A. R., & Pleasure, D. E. (1983). Immune reactions to P2 protein in human inflammatory demyelinative neuropathies. Neurology, 33(2), 234–237. https://doi.org/10.1212/wnl.33.2.234

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

6600513

Department(s)

Administration and Leadership

Document Type

Article