Dynamic organization of developing Purkinje cells revealed by transgene expression.
Publication/Presentation Date
11-1-1991
Abstract
The cerebellum has many properties that make it a useful model for investigating neural development. Purkinje cells, the major output neurons of the cerebellar cortex, have drawn special attention because of the availability of biochemical markers and mutants that affect their development. The spatial expression of L7, a protein specific for Purkinje cells, and L7 beta Gal, a gene expressed in transgenic mice that was constructed from the L7 promoter and the marker beta-galactosidase, delineated bands of Purkinje cells that increased in number during early postnatal development. Expression of the transgene in adult reeler mutant mice, which show inverted cortical lamination, and in primary culture showed that the initial expression of L7 is intrinsic to Purkinje cells and does not depend on extracellular signals. This may reflect an underlying developmental map in cerebellum.
Volume
254
Issue
5032
First Page
719
Last Page
721
ISSN
0036-8075
Published In/Presented At
Smeyne, R. J., Oberdick, J., Schilling, K., Berrebi, A. S., Mugnaini, E., & Morgan, J. I. (1991). Dynamic organization of developing Purkinje cells revealed by transgene expression. Science (New York, N.Y.), 254(5032), 719–721. https://doi.org/10.1126/science.1948052
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
1948052
Department(s)
Administration and Leadership
Document Type
Article