fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system.

Authors

• R J Smeyne
• K Schilling
• L Robertson
• D Luk
• J Oberdick
• T Curran
• J I Morgan

Publication/Presentation Date

1-1-1992

Abstract

A transgenic mouse line containing a fos-lacZ fusion gene was derived in which beta-galactosidase activity identified cell populations expressing fos either constitutively or after stimulation. Seizures and light pulses induced nuclear lacZ activity in defined populations of neurons in vivo, and an array of neurotransmitters, including glutamate, induced the transgene in primary brain cultures. In unstimulated mice, the major sites of fos-lacZ expression were skin, hair follicle, and bone. fos-lacZ mice provide a new avenue for activity mapping studies based on gene expression.

Volume

8

Issue

1

First Page

13

Last Page

23

ISSN

0896-6273

Published In/Presented At

Smeyne, R. J., Schilling, K., Robertson, L., Luk, D., Oberdick, J., Curran, T., & Morgan, J. I. (1992). fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system. Neuron, 8(1), 13–23. https://doi.org/10.1016/0896-6273(92)90105-m

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

1730004

Department(s)

Administration and Leadership

Document Type

Article