Continuous c-fos expression precedes programmed cell death in vivo.
Publication/Presentation Date
5-13-1993
Abstract
The development of a multicellular organism involves a delicate balance among the processes of proliferation, differentiation and death. Naturally occurring cell death aids tissue remodelling, eliminates supernumerary cell populations and provides structural elements such as hair and skin. In the nervous system, selective cell death contributes to the formation and organization of the spinal cord and sympathetic ganglia, retina and corpus callosum. But cell death also occurs in several neuropathological conditions, such as amyelotrophic lateral sclerosis and Alzheimer's disease. Therefore an elucidation of the mechanisms responsible for cell death is critical for an appreciation of both normal development and neuropathological disorders. Using a fos-lacZ transgenic mouse, we provide evidence showing that the continuous expression of Fos, beginning hours or days before the morphological demise of the cell, appears to be a hallmark of terminal differentiation and a harbinger of death.
Volume
363
Issue
6425
First Page
166
Last Page
169
ISSN
0028-0836
Published In/Presented At
Smeyne, R. J., Vendrell, M., Hayward, M., Baker, S. J., Miao, G. G., Schilling, K., Robertson, L. M., Curran, T., & Morgan, J. I. (1993). Continuous c-fos expression precedes programmed cell death in vivo. Nature, 363(6425), 166–169. https://doi.org/10.1038/363166a0
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8483500
Department(s)
Administration and Leadership
Document Type
Article