Control of segment-like patterns of gene expression in the mouse cerebellum.
Publication/Presentation Date
6-1-1993
Abstract
A Purkinje cell-specific transgene, L7-lacZ, is expressed in a series of parasagitally oriented stripes in the mouse cerebellum. This banding pattern can be perturbed by promoter mutation, showing that a combination of positive and negative control elements contributes to the temporal and spatial map of L7 gene expression. In addition to the parasagittal stripes, certain mutations reveal Purkinje cells organized into compartments oriented in the transverse plane of the cerebellum. Transcription factors of the POU or homeobox families appear to be involved in controlling L7 expression in the transverse orientation. Strikingly, some of the domains of gene expression revealed by the mutations appear to correspond to functional compartments of Purkinje cells, thereby suggesting an underlying genetic principle used to orchestrate functional organization in the nervous system.
Volume
10
Issue
6
First Page
1007
Last Page
1018
ISSN
0896-6273
Published In/Presented At
Oberdick, J., Schilling, K., Smeyne, R. J., Corbin, J. G., Bocchiaro, C., & Morgan, J. I. (1993). Control of segment-like patterns of gene expression in the mouse cerebellum. Neuron, 10(6), 1007–1018. https://doi.org/10.1016/0896-6273(93)90050-2
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8318226
Department(s)
Administration and Leadership
Document Type
Article