The role of myelin P2 protein in the production of experimental allergic neuritis.
Publication/Presentation Date
12-1-1984
Abstract
Myelin P2 protein has been proposed as the primary antigen in whole myelin-induced experimental allergic neuritis (EAN). We investigated the neuritogenic properties of P2 by sensitizing Lewis rats with complete Freund's adjuvant (CFA) containing P2, P2 plus phosphatidyl serine, or whole myelin containing an equivalent amount of P2. Animals were examined using a battery of clinical, electrophysiological, immunological, and morphological methods. Myelin-immunized rats developed the characteristic features of EAN. P2-sensitized rats developed a similar but much less intense disorder. When rats were sensitized with P2 in the presence of phosphatidyl serine, however, they developed radiculoneuropathy that was indistinguishable from myelin-induced EAN. Inoculation with phosphatidyl serine plus complete Freund's adjuvant or complete Freund's adjuvant alone had no detectable effect on peripheral nerves. These studies demonstrate that sensitization of rats with a single myelin antigen, P2 protein, is sufficient to induce the clinical, electrophysiological, and neuropathological features of EAN.
Volume
16
Issue
6
First Page
680
Last Page
685
ISSN
0364-5134
Published In/Presented At
Rostami, A., Brown, M. J., Lisak, R. P., Sumner, A. J., Zweiman, B., & Pleasure, D. E. (1984). The role of myelin P2 protein in the production of experimental allergic neuritis. Annals of neurology, 16(6), 680–685. https://doi.org/10.1002/ana.410160610
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
6084458
Department(s)
Administration and Leadership
Document Type
Article