Transfer of experimental allergic neuritis with P2-reactive T-cell lines.

Authors

• A Rostami
• J B Burns
• M J Brown
• J Rosen
• B Zweiman
• R P Lisak
• D E Pleasure

Publication/Presentation Date

4-1-1985

Abstract

Experimental allergic neuritis (EAN) was induced in normal Lewis rats by systemic passive transfer of T-cell lines responding to P2 protein. These cells had predominantly helper phenotype and could induce EAN within 7 days following adoptive transfer. There was no anti-P2 antibody response in the recipients of the P2-reactive cells recovered from donors with high anti-P2 antibody levels. This study provides direct evidence that T cells are important for the induction of EAN. Furthermore, there was no evidence of a pathogenic role for anti-P2 antibody in passive EAN.

Volume

91

Issue

2

First Page

354

Last Page

361

ISSN

0008-8749

Published In/Presented At

Rostami, A., Burns, J. B., Brown, M. J., Rosen, J., Zweiman, B., Lisak, R. P., & Pleasure, D. E. (1985). Transfer of experimental allergic neuritis with P2-reactive T-cell lines. Cellular immunology, 91(2), 354–361. https://doi.org/10.1016/0008-8749(85)90233-3

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

2581699

Department(s)

Administration and Leadership

Document Type

Article