Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling.
Publication/Presentation Date
6-30-2017
Abstract
Circuits in the auditory cortex are highly susceptible to acoustic influences during an early postnatal critical period. The auditory cortex selectively expands neural representations of enriched acoustic stimuli, a process important for human language acquisition. Adults lack this plasticity. Here we show in the murine auditory cortex that juvenile plasticity can be reestablished in adulthood if acoustic stimuli are paired with disruption of ecto-5'-nucleotidase-dependent adenosine production or A
Volume
356
Issue
6345
First Page
1352
Last Page
1356
ISSN
1095-9203
Published In/Presented At
Blundon, J. A., Roy, N. C., Teubner, B. J. W., Yu, J., Eom, T. Y., Sample, K. J., Pani, A., Smeyne, R. J., Han, S. B., Kerekes, R. A., Rose, D. C., Hackett, T. A., Vuppala, P. K., Freeman, B. B., 3rd, & Zakharenko, S. S. (2017). Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling. Science (New York, N.Y.), 356(6345), 1352–1356. https://doi.org/10.1126/science.aaf4612
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
28663494
Department(s)
Administration and Leadership
Document Type
Article