Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis.

Authors

• Shankar Sadasivan
• Bridgett Sharp
• Stacey Schultz-Cherry
• Richard Jay Smeyne

Publication/Presentation Date

1-1-2017

Abstract

Central Nervous System inflammation has been implicated in neurodegenerative disorders including Parkinson's disease (Ransohoff, Science 353: 777-783, 2016; Kannarkat et al. J. Parkinsons Dis. 3: 493-514, 2013). Here, we examined if the H1N1 influenza virus (Studahl et al. Drugs 73: 131-158, 2013) could synergize with the parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (Jackson-Lewis et al. in Mark LeDoux (ed)

Volume

3

First Page

18

Last Page

18

ISSN

2373-8057

Published In/Presented At

Sadasivan, S., Sharp, B., Schultz-Cherry, S., & Smeyne, R. J. (2017). Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis. NPJ Parkinson's disease, 3, 18. https://doi.org/10.1038/s41531-017-0019-z

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

28649618

Department(s)

Administration and Leadership

Document Type

Article