Evolution of the cellular response in P2-induced experimental allergic neuritis.
Publication/Presentation Date
1-1-1992
Abstract
We examined the development of the inflammatory cellular response and demyelination in P2 protein-induced experimental allergic neuritis (EAN). Collections of inflammatory cells were first identified in nerve roots 14 days after immunization. Ia+ cells predominated in the evolving lesions and T-helper cells were the dominant T-cell type with T-suppressor/cytotoxic cells appearing later in the course of the disease. Vesiculation, the earliest change seen in the myelin sheath, appeared before the wave of cellular infiltration. These results indicate that myelin injury precedes inflammation in P2 protein-induced EAN, and provide further evidence that this disorder is indistinguishable from EAN induced with whole peripheral nerve myelin.
Volume
60
Issue
2
First Page
108
Last Page
112
ISSN
1015-2008
Published In/Presented At
Rosen, J. L., Brown, M. J., & Rostami, A. (1992). Evolution of the cellular response in P2-induced experimental allergic neuritis. Pathobiology : journal of immunopathology, molecular and cellular biology, 60(2), 108–112. https://doi.org/10.1159/000163707
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
1373941
Department(s)
Administration and Leadership
Document Type
Article