Isolation of P2 protein--reactive T-cell lines from human blood.
Publication/Presentation Date
4-1-1986
Abstract
Human T-cell lines reactive with the peripheral nerve myelin protein, P2 protein, were isolated from the peripheral blood of 4 normal persons and 1 patient with Guillain-Barré syndrome. These predominantly helper phenotype T-cell lines were isolated and maintained in vitro by antigen stimulation followed by culture with interleukin 2. Myelin basic protein-reactive T cells were also isolated in parallel from the same subjects as antigen specificity controls. T cells recognizing myelin basic protein did not respond to P2 protein, nor did P2-reactive cells respond to myelin basic protein. These findings suggest that a potential for autoimmune reactivity with peripheral nervous system myelin antigens may exist for both normal persons and some patients with neurological disease.
Volume
19
Issue
4
First Page
391
Last Page
393
ISSN
0364-5134
Published In/Presented At
Burns, J., Krasner, L. J., Rostami, A., & Pleasure, D. (1986). Isolation of P2 protein--reactive T-cell lines from human blood. Annals of neurology, 19(4), 391–393. https://doi.org/10.1002/ana.410190416
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2423017
Department(s)
Administration and Leadership
Document Type
Article