Urinary free kappa light chain levels in chronic progressive multiple sclerosis.
Publication/Presentation Date
1-1-1994
Abstract
Previous studies have shown elevated levels of free kappa light chains (FKLC) in the urine of patients with relapsing-remitting multiple sclerosis (MS). The levels correlated well with clinical relapses, indicating that they could serve as useful markers of disease activity. In this study, we performed monthly measurements of urinary FKLC in patients with the chronic progressive form of MS, and correlated them with clinical indicators of disease activity, as expressed by Kurtzke's expanded disability status scale (EDSS) and brain magnetic resonance imaging (MRI). We noted wide fluctuations in the FKLC levels, which correlated poorly with EDSS scores or MRI changes. Longer follow-up periods may be needed before definite conclusions can be drawn.
Volume
62
Issue
1
First Page
29
Last Page
33
ISSN
1015-2008
Published In/Presented At
Constantinescu, C. S., Mehta, P. D., & Rostami, A. M. (1994). Urinary free kappa light chain levels in chronic progressive multiple sclerosis. Pathobiology : journal of immunopathology, molecular and cellular biology, 62(1), 29–33. https://doi.org/10.1159/000163874
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8031473
Department(s)
Administration and Leadership
Document Type
Article