Pathogenesis of neuroimmunologic diseases. Experimental models.
Publication/Presentation Date
1-1-1998
Abstract
Animal models of autoimmune diseases have greatly improved our current understanding of the pathogenesis of human autoimmunity and have provided the potential for therapies based on manipulation of the immune system. In our laboratory, we have investigated the immunopathogenesis of autoimmune diseases of the nervous system and muscle. We have developed immune-based approaches for the suppression of experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), and experimental autoimmune neuritis (EAN), a model for the Guillain-Barré syndrome (GBS). These approaches included induction of peripheral tolerance, immunotoxin targeting of activated T cells, and cytokine manipulations. In addition, we identified the antigen and characterized immunopathologically an autoimmune inflammatory disease of skeletal muscle, experimental autoimmune myositis (EAM), a model for the human inflammatory muscle disease polymyositis.
Volume
17
Issue
1-2
First Page
217
Last Page
227
ISSN
0257-277X
Published In/Presented At
Constantinescu, C. S., Hilliard, B., Fujioka, T., Bhopale, M. K., Calida, D., & Rostami, A. M. (1998). Pathogenesis of neuroimmunologic diseases. Experimental models. Immunologic research, 17(1-2), 217–227. https://doi.org/10.1007/BF02786446
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
9479583
Department(s)
Administration and Leadership
Document Type
Article