Suppression of experimental autoimmune neuritis by phosphodiesterase inhibitor pentoxifylline.
Publication/Presentation Date
11-1-1996
Abstract
Phosphodiesterase inhibitor pentoxifylline (POX) has been shown to have multiple immunomodulatory effects in vitro and in vivo. It inhibits T cell proliferation, T helper 1-type cytokines, and tumor necrosis factor. We postulated that POX might have an in vivo immunomodulatory effect on a T-cell-mediated autoimmune peripheral nervous system disease, experimental autoimmune neuritis (EAN). We investigated the effect of POX on EAN in rats immunized with peripheral nerve myelin containing neuritogenic peptide SP26. At 200 mg/kg/day, there was significant suppression of clinical EAN, weight loss, and T cell proliferation to SP26 compared to controls. Proliferation of T cells from immunized rats to SP26 was suppressed by POX in vitro. These studies demonstrate a beneficial role for POX in EAN, with potential applicability to human autoimmune demyelination.
Volume
143
Issue
1-2
First Page
14
Last Page
18
ISSN
0022-510X
Published In/Presented At
Constantinescu, C. S., Hilliard, B., Lavi, E., Ventura, E., Venkatesh, V., & Rostami, A. (1996). Suppression of experimental autoimmune neuritis by phosphodiesterase inhibitor pentoxifylline. Journal of the neurological sciences, 143(1-2), 14–18. https://doi.org/10.1016/s0022-510x(96)00195-5
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8981293
Department(s)
Administration and Leadership
Document Type
Article