IL-12 reverses the suppressive effect of the CD40 ligand blockade on experimental autoimmune encephalomyelitis (EAE).

Authors

• C S Constantinescu
• B Hilliard
• M Wysocka
• E S Ventura
• M K Bhopale
• G Trinchieri
• A M Rostami

Publication/Presentation Date

12-1-1999

Abstract

Blockade of the CD40 ligand (CD40L)-CD40 interaction suppresses experimental autoimmune encephalomyelitis (EAE). Since this interaction induces IL-12, an essential cytokine for EAE induction, we hypothesized that CD40L blockade may suppress EAE through IL-12 inhibition. Here we show that exogenous IL-12 abolishes the ability of anti-CD40L monoclonal antibodies to prevent EAE. Anti-IL-12 antibodies prevent this reversal and protect from EAE. These results show that IL-12 is sufficient to overcome CD40L blockade and suggest that, of the multiple consequences of the CD40L-CD40 interaction, IL-12 induction is an essential one for induction of EAE.

Volume

171

Issue

1

First Page

60

Last Page

64

ISSN

0022-510X

Published In/Presented At

Constantinescu, C. S., Hilliard, B., Wysocka, M., Ventura, E. S., Bhopale, M. K., Trinchieri, G., & Rostami, A. M. (1999). IL-12 reverses the suppressive effect of the CD40 ligand blockade on experimental autoimmune encephalomyelitis (EAE). Journal of the neurological sciences, 171(1), 60–64. https://doi.org/10.1016/s0022-510x(99)00249-x

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

10567051

Department(s)

Administration and Leadership

Document Type

Article