Free light chains in multiple sclerosis urine.
Publication/Presentation Date
6-1-1998
Abstract
We measured free kappa (kappa) and lambda (lambda) light chains in urine from patients with definite multiple sclerosis (MS), other neurologic diseases (OND), and normal controls by using an enzyme linked immunosorbent assay. Both kappa and lambda light chains were higher in MS than OND or controls. In seven of eight relapsing-remitting (R-R) MS patients serial studies showed that urinary kappa chains were elevated during periods of worsening, and decreased during clinical recovery. In contrast, the levels of kappa chains did not correlate with clinical activity in 10 progressive (P) MS patients. Further correlation of urinary light chains with neurologic evaluations in R-R and P MS patients over a longer period are needed to determine their clinical and biological relevance.
Volume
4
Issue
3
First Page
254
Last Page
256
ISSN
1352-4585
Published In/Presented At
Mehta, P. D., Cook, S. D., Coyle, P. K., Troiano, R. A., Constantinescu, C. S., & Rostami, A. M. (1998). Free light chains in multiple sclerosis urine. Multiple sclerosis (Houndmills, Basingstoke, England), 4(3), 254–256. https://doi.org/10.1177/135245859800400331
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
9762684
Department(s)
Administration and Leadership
Document Type
Article