A paradoxical role of APCs in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis.
Publication/Presentation Date
4-1-2005
Abstract
The central role of T cells in the induction of tolerance to autoantigens has been well documented. However, the role of antigen-presenting cells (APCs) in this process is not yet fully understood. To better understand the contribution of APCs in tolerance, we studied the interaction of purified APCs and CD4(+) T cells in a model of intravenous (i.v.) tolerance to experimental autoimmune encephalomyelitis (EAE). As expected, we found that T cells were tolerized to the autoantigen after i.v. injection. However, purified APCs obtained from MOG-i.v.-treated mice were paradoxically immuno-stimulatory, as they induced a non-specific Th1-type response both in vitro and in vivo. We conclude that blocking such APC activation would enhance the effectiveness of tolerance induction.
Volume
161
Issue
1-2
First Page
101
Last Page
112
ISSN
0165-5728
Published In/Presented At
Zhang, G. X., Yu, S., Li, Y., Ventura, E. S., Gran, B., & Rostami, A. (2005). A paradoxical role of APCs in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 161(1-2), 101–112. https://doi.org/10.1016/j.jneuroim.2004.12.017
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15748949
Department(s)
Administration and Leadership
Document Type
Article