Early administration of IL-12 suppresses EAE through induction of interferon-gamma.
Publication/Presentation Date
11-1-2004
Abstract
Recent findings have shown that IL-12, a key inducer of Th1 cell development, is not required in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) as severe CNS inflammatory demyelination can develop in the absence of IL-12 or IL-12 responsiveness. These data raised the possibility of an immunomodulatory action of IL-12 in this disease model. We show here that IL-12 suppresses MOG35-55-induced EAE in the C57BL/6 mouse when administered during the early induction phase of the disease. The inhibitory effect is interferon-gamma-(IFN-gamma)-dependent, as clearly shown by lack of suppression in IFN-gamma-deficient mice, and is also accompanied by inhibition of mRNA expression of the proinflammatory cytokine IL-17.
Volume
156
Issue
1-2
First Page
123
Last Page
131
ISSN
0165-5728
Published In/Presented At
Gran, B., Chu, N., Zhang, G. X., Yu, S., Li, Y., Chen, X. H., Kamoun, M., & Rostami, A. (2004). Early administration of IL-12 suppresses EAE through induction of interferon-gamma. Journal of neuroimmunology, 156(1-2), 123–131. https://doi.org/10.1016/j.jneuroim.2004.07.019
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15465603
Department(s)
Administration and Leadership
Document Type
Article