T cells, cytokines, and autoantigens in multiple sclerosis.
Publication/Presentation Date
5-1-2001
Abstract
In multiple sclerosis (MS), inflammatory demyelination in the central nervous system is thought to be initiated by T cells that recognize myelin antigens. T cells are the main regulators of acquired immunity and are involved in the pathogenesis of several organ-specific autoimmune diseases. This review provides an overview of recent studies on the role of T cells in autoimmune demyelination. Because autoreactive T cells are normally present in the mature repertoire of T cells in the blood and lymphoid organs of MS patients, but also in normal controls, particular attention is devoted to the mechanisms of activation and the functional phenotype of such T cells in patients with MS. The role of cytokines as effector molecules and the main candidate antigens are also discussed.
Volume
1
Issue
3
First Page
263
Last Page
270
ISSN
1528-4042
Published In/Presented At
Gran, B., & Rostami, A. (2001). T cells, cytokines, and autoantigens in multiple sclerosis. Current neurology and neuroscience reports, 1(3), 263–270. https://doi.org/10.1007/s11910-001-0029-3
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
11898528
Department(s)
Administration and Leadership
Document Type
Article