Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5).
Publication/Presentation Date
10-1-2001
Abstract
We screened for genes whose expression is significantly up- or downregulated during Wallerian degeneration in adult rat sciatic nerve with cDNA arrays. Fibroblast growth factor-5 (FGF-5) mRNA seemed to be induced. This was confirmed by northern blotting and in situ hybridization, as well as Western blotting for FGF-5 in axotomized nerve. Axon-Schwann cell interactions decreased the steady-state level of FGF-5 mRNA in regenerating sciatic nerves, and forskolin diminished its expression in cultured Schwann cells. We conclude that denervated Schwann cells synthesize FGF-5, which is a secreted, neuronotrophic member of the FGF family.
Volume
66
Issue
1
First Page
16
Last Page
22
ISSN
0360-4012
Published In/Presented At
Scarlato, M., Xu, T., Bannerman, P., Beesley, J., Reddy, U. R., Rostami, A., Scherer, S. S., & Pleasure, D. (2001). Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5). Journal of neuroscience research, 66(1), 16–22. https://doi.org/10.1002/jnr.1193
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
11598998
Department(s)
Administration and Leadership
Document Type
Article