Serial evoked potential studies and MRI imaging in chronic progressive multiple sclerosis.
Publication/Presentation Date
12-15-1999
Abstract
Measurements of serial evoked potential latencies and plaque burden on MRI scans are often obtained during clinical studies of multiple sclerosis patients to provide additional information to the disability-based primary endpoints. The ideal laboratory-based marker of progression would be expected to significantly change over the time period of study. Serial visual (VEP) and brainstem auditory evoked potentials (BAEP) and MRI scans of 11 chronic progressive MS patients were obtained over a 1.5 year period in a clinical study. Over this period, there was no significant change in disability as measured by the Kurtzke EDSS, Ambulation Index or Neurological Rating Score. The VEP P100 significantly progressed over the period of study. However, the MRI T(2) plaque burden and BAEP I-V intrapeak latency did not significantly progress over the 1.5 years. We conclude that, in chronic progressive MS, serial visual evoked potential tests may complement standard disability-based endpoints to assess disease progression.
Volume
171
Issue
2
First Page
79
Last Page
83
ISSN
0022-510X
Published In/Presented At
Sater, R. A., Rostami, A. M., Galetta, S., Farber, R. E., & Bird, S. J. (1999). Serial evoked potential studies and MRI imaging in chronic progressive multiple sclerosis. Journal of the neurological sciences, 171(2), 79–83. https://doi.org/10.1016/s0022-510x(99)00255-5
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
10581371
Department(s)
Administration and Leadership
Document Type
Article