Anti-interleukin-12 antibody: potential role in preventing relapses of multiple sclerosis.

Publication/Presentation Date

4-1-2000

Abstract

Multiple sclerosis is an inflammatory demyelinating disorder of the central nervous system. Immunological evidence from patients with multiple sclerosis and experimental models suggests that the cytokine interleukin-12 (IL-12) plays an important role in the pathogenesis of inflammatory demyelination. In experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, antibodies that block IL-12 can prevent relapses of the disease. Anti-IL-12 antibodies present a novel approach for preventing relapses in multiple sclerosis.

Volume

13

Issue

4

First Page

233

Last Page

241

ISSN

1173-8804

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

18034530

Department(s)

Administration and Leadership

Document Type

Article

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