Antigen presenting cells treated in vitro by macrophage colony-stimulating factor and autoantigen protect mice from autoimmunity.
Publication/Presentation Date
12-1-2007
Abstract
Macrophage colony-stimulating factor (M-CSF) is a critical cytokine in the development of monocytic lineage and may have immunoregulatory properties. Here we show that peritoneal antigen presenting cells (APCs) treated with M-CSF produced decreased levels of proinflammatory cytokines IFN-gamma, TNF-alpha and IL-12. These APCs treated with M-CSF+autoantigen peptide significantly suppressed antigen-specific T cell proliferation, induced regulatory CD4(+) and CD8(+) T cells in vitro and in vivo, and significantly suppressed experimental autoimmune encephalomyelitis (EAE). Thus, in vitro treatment of APCs with M-CSF+autoantigen can be a novel therapeutic option for autoimmune diseases.
Volume
192
Issue
1-2
First Page
68
Last Page
78
ISSN
0165-5728
Published In/Presented At
Guan, Y., Yu, S., Zhao, Z., Ciric, B., Zhang, G. X., & Rostami, A. (2007). Antigen presenting cells treated in vitro by macrophage colony-stimulating factor and autoantigen protect mice from autoimmunity. Journal of neuroimmunology, 192(1-2), 68–78. https://doi.org/10.1016/j.jneuroim.2007.09.021
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18006080
Department(s)
Administration and Leadership
Document Type
Article