IDO: a double-edged sword for T(H)1/T(H)2 regulation.
Publication/Presentation Date
11-16-2008
Abstract
Indoleamine 2,3-dioxygenase (IDO) has been well defined as one of the important immunosuppressive properties for T(H)1 cell-mediated immune responses, but its function in T(H)2 dominant system is poorly understood. Recently, an appreciable number of publications suggest that the role of IDO in T(H)2 cell regulation may be different from that of T(H)1 immune responses. Here we review the evidence on the regulatory function of IDO and tryptophan metabolites in T(H)1/T(H)2 differentiation. We propose that IDO-kynurenine pathway can serve as a negative feedback loop for T(H)1 cells but it may play a distinct role in up-regulating T(H)2 dominant immune responses.
Volume
121
Issue
1
First Page
1
Last Page
6
ISSN
0165-2478
Published In/Presented At
Xu, H., Zhang, G. X., Ciric, B., & Rostami, A. (2008). IDO: a double-edged sword for T(H)1/T(H)2 regulation. Immunology letters, 121(1), 1–6. https://doi.org/10.1016/j.imlet.2008.08.008
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18824197
Department(s)
Administration and Leadership
Document Type
Article