Therapeutic potential of IL-27 in multiple sclerosis?
Publication/Presentation Date
2-1-2009
Abstract
BACKGROUND: Multiple sclerosis (MS) is a debilitating neurological disease, characterized by inflammatory demyelination and axonal degeneration in the CNS. Currently approved therapies are partially effective, however safer and more effective treatments are needed.
OBJECTIVE/METHODS: To assess the therapeutic potential of the heterodimeric cytokine, IL-27 in MS, based on the current literature.
RESULTS/CONCLUSIONS: IL-27 exerts profound anti-inflammatory effects in several infectious and experimental autoimmune models. In particular, suppressive effects on helper T cells, which are implicated in the pathogenesis of MS, suggest that IL-27 may be therapeutically relevant in MS. However, while exciting discoveries have been made, further work is required particularly in human health and disease, to understand the diverse roles of IL-27 and its therapeutic potential.
Volume
9
Issue
2
First Page
149
Last Page
160
ISSN
1744-7682
Published In/Presented At
Fitzgerald, D. C., & Rostami, A. (2009). Therapeutic potential of IL-27 in multiple sclerosis?. Expert opinion on biological therapy, 9(2), 149–160. https://doi.org/10.1517/14712590802646936
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19236245
Department(s)
Administration and Leadership
Document Type
Article