T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis.
Publication/Presentation Date
1-1-2010
Abstract
One of the reasons multiple sclerosis (MS) has been considered a T-cell mediated autoimmune disease is that a similar experimental disease can be induced in certain rodents and primates by immunization with myelin antigens, leading to T-cell-mediated inflammatory demyelination in the CNS. In addition, most if not all pharmacological treatments available for MS are biologically active on T cells. In this article we review the principles of T-cell-based immunotherapies and the specific actions of current and novel treatments on T-cell functions, when these are known. For both licensed and innovative agents, we also discuss biological actions on other immune cell types. Finally, we offer a brief perspective on expected changes in the use of MS immunotherapies in the near future.
Volume
2
Issue
1
First Page
99
Last Page
115
ISSN
1750-7448
Published In/Presented At
O'Brien, K., Gran, B., & Rostami, A. (2010). T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunotherapy, 2(1), 99–115. https://doi.org/10.2217/imt.09.61
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
20231863
Department(s)
Administration and Leadership
Document Type
Article