Mechanisms of immunological tolerance in central nervous system inflammatory demyelination.
Publication/Presentation Date
8-1-2015
Abstract
Multiple sclerosis is a complex autoimmune disease of the central nervous system that results in a disruption of the balance between pro-inflammatory and anti-inflammatory signals in the immune system. Given that central nervous system inflammation can be suppressed by various immunological tolerance mechanisms, immune tolerance has become a focus of research in the attempt to induce long-lasting immune suppression of pathogenic T cells. Mechanisms underlying this tolerance induction include induction of regulatory T cell populations, anergy and the induction of tolerogenic antigen-presenting cells. The intravenous administration of encephalitogenic peptides has been shown to suppress experimental autoimmune encephalomyelitis and induce tolerance by promoting the generation of regulatory T cells and inducing apoptosis of pathogenic T cells. Safe and effective methods of inducing long-lasting immune tolerance are essential for the treatment of multiple sclerosis. By exploring tolerogenic mechanisms, new strategies can be devised to strengthen the regulatory, anti-inflammatory cell populations thereby weakening the pathogenic, pro-inflammatory cell populations.
Volume
6
Issue
3
First Page
264
Last Page
274
ISSN
1759-1961
Published In/Presented At
Mari, E. R., Moore, J. N., Zhang, G. X., & Rostami, A. (2015). Mechanisms of immunological tolerance in central nervous system inflammatory demyelination. Clinical & experimental neuroimmunology, 6(3), 264–274. https://doi.org/10.1111/cen3.12196
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
26425145
Department(s)
Administration and Leadership
Document Type
Article