IL-12Rβ2 has a protective role in relapsing-remitting experimental autoimmune encephalomyelitis.
Publication/Presentation Date
2-15-2016
Abstract
IL-12Rβ2 is a common receptor subunit of heterodimeric receptors for IL-12 and IL-35, two cytokines that are implicated in immunopathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. We evaluated the role of IL-12Rβ2 in relapsing-remitting EAE (RR-EAE). IL-12Rβ2-deficient SJL/J mice developed markedly more severe clinical EAE, and had greater mortality and more severe relapses compared with wild-type controls. IL-12Rβ2-deficient EAE mice also had more infiltrating mononuclear cells in the CNS, as well as higher T cell proliferative capacity and decreased IFN-γ production at the periphery. These findings demonstrate a protective role of IL-12Rβ2 in RR-EAE.
Volume
291
First Page
59
Last Page
69
ISSN
1872-8421
Published In/Presented At
Xie, C., Ciric, B., Yu, S., Zhang, G. X., & Rostami, A. (2016). IL-12Rβ2 has a protective role in relapsing-remitting experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 291, 59–69. https://doi.org/10.1016/j.jneuroim.2015.12.009
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
26857496
Department(s)
Administration and Leadership
Document Type
Article