Elevated expression of granulocyte-macrophage colony-stimulating factor receptor in multiple sclerosis lesions.
Publication/Presentation Date
4-15-2018
Abstract
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease that disproportionately affects young adults, leading to disability and high costs to society. Infiltration of T cells and monocytes into the central nervous system (CNS) is critical for disease initiation and progression. However, despite a great deal of effort the molecular mechanisms by which immune cells initiate and perpetuate CNS damage in MS have not yet been elucidated. In experimental autoimmune encephalomyelitis (EAE), an animal model of MS, granulocyte-macrophage colony-stimulating factor (GM-CSF) produced by pathogenic Th1 and Th17 cells is critical for the recruitment of monocytes into the CNS during the initial stage of disease. We and others have recently shown that, compared with healthy individuals, MS patients have greater numbers of CD4
Volume
317
First Page
45
Last Page
54
ISSN
1872-8421
Published In/Presented At
Imitola, J., Rasouli, J., Watanabe, F., Mahajan, K., Sharan, A. D., Ciric, B., Zhang, G. X., & Rostami, A. (2018). Elevated expression of granulocyte-macrophage colony-stimulating factor receptor in multiple sclerosis lesions. Journal of neuroimmunology, 317, 45–54. https://doi.org/10.1016/j.jneuroim.2017.12.017
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
29290406
Department(s)
Administration and Leadership
Document Type
Article