Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination
Publication/Presentation Date
1-1-2019
Abstract
Myelination, which occurs predominantly postnatally and continues throughout life, is important for proper neurologic function of the mammalian central nervous system (CNS). We have previously demonstrated that the combination therapy of fingolimod (FTY720) and transplanted neural stem cells (NSCs) had a significantly enhanced therapeutic effect on the chronic stage of experimental autoimmune encephalomyelitis, an animal model of CNS autoimmunity, compared to using either one of them alone. However, reduced disease severity may be secondary to the immunomodulatory effects of FTY720 and NSCs, while whether this therapy directly affects myelinogenesis remains unknown. To investigate this important question, we used three myelination models under minimal or non-inflammatory microenvironments. Our results showed that FTY720 drives NSCs to differentiate into oligodendrocytes and promotes myelination in an
Volume
13
First Page
14
Last Page
14
ISSN
1662-5102
Published In/Presented At
Zhang, Y., Lu, X. Y., Ye, Z. Q., Ciric, B., Ma, C. G., Rostami, A., Li, X., & Zhang, G. X. (2019). Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination in vivo Through a Non-immunomodulatory Mechanism. Frontiers in cellular neuroscience, 13, 14. https://doi.org/10.3389/fncel.2019.00014
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
30804753
Department(s)
Administration and Leadership
Document Type
Article