IL-9 Controls Central Nervous System Autoimmunity by Suppressing GM-CSF Production.

Authors

• Satoshi Yoshimura
• Rodolfo Thome
• Shingo Konno
• Elisabeth R Mari
• Javad Rasouli
• Daniel Hwang
• Alexandra Boehm
• Yanhua Li
• Guang-Xian Zhang
• Bogoljub Ciric
• Abdolmohamad Rostami

Publication/Presentation Date

2-1-2020

Abstract

Multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) are inflammatory diseases of the CNS in which Th17 cells play a major role in the disease pathogenesis. Th17 cells that secrete GM-CSF are pathogenic and drive inflammation of the CNS. IL-9 is a cytokine with pleiotropic functions, and it has been suggested that it controls the pathogenic inflammation mediated by Th17 cells, and IL-9R

Volume

204

Issue

3

First Page

531

Last Page

539

ISSN

1550-6606

Published In/Presented At

Yoshimura, S., Thome, R., Konno, S., Mari, E. R., Rasouli, J., Hwang, D., Boehm, A., Li, Y., Zhang, G. X., Ciric, B., & Rostami, A. (2020). IL-9 Controls Central Nervous System Autoimmunity by Suppressing GM-CSF Production. Journal of immunology (Baltimore, Md. : 1950), 204(3), 531–539. https://doi.org/10.4049/jimmunol.1801113

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

31852750

Department(s)

Administration and Leadership

Document Type

Article