Role of extracellular vesicles in neurodegenerative diseases.
Publication/Presentation Date
6-1-2021
Abstract
Extracellular vesicles (EVs) are heterogeneous cell-derived membranous structures that arise from the endosome system or directly detach from the plasma membrane. In recent years, many advances have been made in the understanding of the clinical definition and pathogenesis of neurodegenerative diseases, but translation into effective treatments is hampered by several factors. Current research indicates that EVs are involved in the pathology of diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). Besides, EVs are also involved in the process of myelin formation, and can also cross the blood-brain barrier to reach the sites of CNS injury. It is suggested that EVs have great potential as a novel therapy for the treatment of neurodegenerative diseases. Here, we reviewed the advances in understanding the role of EVs in neurodegenerative diseases and addressed the critical function of EVs in the CNS. We have also outlined the physiological mechanisms of EVs in myelin regeneration and highlighted the therapeutic potential of EVs in neurodegenerative diseases.
Volume
201
First Page
102022
Last Page
102022
ISSN
1873-5118
Published In/Presented At
Xiao, Y., Wang, S. K., Zhang, Y., Rostami, A., Kenkare, A., Casella, G., Yuan, Z. Q., & Li, X. (2021). Role of extracellular vesicles in neurodegenerative diseases. Progress in neurobiology, 201, 102022. https://doi.org/10.1016/j.pneurobio.2021.102022
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
33617919
Department(s)
Administration and Leadership
Document Type
Article