Dimethyl fumarate suppresses granulocyte macrophage colony-stimulating factor-producing Th1 cells in CNS neuroinflammation.

Authors

• Farinaz Safavi
• Rodolfo Thome
• Zichen Li
• Guang-Xian Zhang
• Abdolmohamad Rostami

Publication/Presentation Date

7-1-2020

Abstract

OBJECTIVE: To study the immunomodulatory effect of dimethyl fumarate (DF) on granulocyte macrophage colony-stimulating factor (GM-CSF) production in CD4

METHODS: We collected splenocytes and CD4

RESULTS: DF acts directly on CD4

CONCLUSIONS: We suggest that DF exclusively suppresses GM-CSF-producing Th1 cells in both animal and human CD4

Volume

7

Issue

4

ISSN

2332-7812

Published In/Presented At

Safavi, F., Thome, R., Li, Z., Zhang, G. X., & Rostami, A. (2020). Dimethyl fumarate suppresses granulocyte macrophage colony-stimulating factor-producing Th1 cells in CNS neuroinflammation. Neurology(R) neuroimmunology & neuroinflammation, 7(4), e729. https://doi.org/10.1212/NXI.0000000000000729

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

32371548

Department(s)

Administration and Leadership

Document Type

Article