RNA-Binding Protein HuR Promotes Th17 Cell Differentiation and Can Be Targeted to Reduce Autoimmune Neuroinflammation.

Authors

• Jing Chen
• Jennifer L Martindale
• Kotb Abdelmohsen
• Gaurav Kumar
• Paolo M Fortina
• Myriam Gorospe
• Abdolmohamad Rostami
• Shiguang Yu

Publication/Presentation Date

4-15-2020

Abstract

Dysregulated Th17 cell differentiation is associated with autoimmune diseases such as multiple sclerosis, which has no curative treatment. Understanding the molecular mechanisms of regulating Th17 cell differentiation will help find a novel therapeutic target for treating Th17 cell-mediated diseases. In this study, we investigated the cell-intrinsic processes by which RNA-binding protein HuR orchestrates Th17 cell fate decisions by posttranscriptionally regulating transcription factors

Volume

204

Issue

8

First Page

2076

Last Page

2087

ISSN

1550-6606

Published In/Presented At

Chen, J., Martindale, J. L., Abdelmohsen, K., Kumar, G., Fortina, P. M., Gorospe, M., Rostami, A., & Yu, S. (2020). RNA-Binding Protein HuR Promotes Th17 Cell Differentiation and Can Be Targeted to Reduce Autoimmune Neuroinflammation. Journal of immunology (Baltimore, Md. : 1950), 204(8), 2076–2087. https://doi.org/10.4049/jimmunol.1900769

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

32169842

Department(s)

Administration and Leadership

Document Type

Article