CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology.

Authors

• Dan Xiao
• Weifeng Zhang
• Qing Wang
• Xing Li
• Yuan Zhang
• Javad Rasouli
• Giacomo Casella
• Bogoljub Ciric
• Mark Curtis
• Abdolmohamad Rostami
• Guang-Xian Zhang

Publication/Presentation Date

3-12-2021

Abstract

Inducible conditional knockout mice are important tools for studying gene function and disease therapy, but their generation is costly and time-consuming. We introduced clustered regularly interspaced short palindromic repeats (CRISPR) and

Volume

20

First Page

755

Last Page

764

ISSN

2329-0501

Published In/Presented At

Xiao, D., Zhang, W., Wang, Q., Li, X., Zhang, Y., Rasouli, J., Casella, G., Ciric, B., Curtis, M., Rostami, A., & Zhang, G. X. (2021). CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology. Molecular therapy. Methods & clinical development, 20, 755–764. https://doi.org/10.1016/j.omtm.2021.02.012

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

33738329

Department(s)

Administration and Leadership

Document Type

Article