Oral D-mannose treatment suppresses experimental autoimmune encephalomyelitis via induction of regulatory T cells.
Publication/Presentation Date
1-15-2022
Abstract
D-mannose (D-m) is a glucose epimer found in natural products, especially fruits. In mouse models of diabetes and airway inflammation, D-m supplementation via drinking water attenuated pathology by modifying cellular energy metabolism, leading to the activation of latent transforming growth factor beta (TGF-β), which in turn induced T regulatory cells (Tregs). Given that Tregs are important in controlling neuroinflammation in experimental autoimmune encephalomyelitis (EAE) and likely in multiple sclerosis (MS), we hypothesized that D-m could also suppress EAE. We found that D-m delayed disease onset and reduced disease severity in two models of EAE. Importantly, D-m treatment prevented relapses in a relapsing-remitting model of EAE, which mimics the most common clinical manifestation of MS. EAE suppression was accompanied by increased frequency of CD4
Volume
362
First Page
577778
Last Page
577778
ISSN
1872-8421
Published In/Presented At
Hwang, D., Boehm, A., Rostami, A., Zhang, G. X., & Ciric, B. (2022). Oral D-mannose treatment suppresses experimental autoimmune encephalomyelitis via induction of regulatory T cells. Journal of neuroimmunology, 362, 577778. https://doi.org/10.1016/j.jneuroim.2021.577778
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
34814011
Department(s)
Administration and Leadership
Document Type
Article