IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system.
Publication/Presentation Date
6-27-2023
Abstract
The objective of this study is to examine IL-11-induced mechanisms of inflammatory cell migration to the central nervous system (CNS). We report that IL-11 is produced at highest frequency by myeloid cells among the peripheral blood mononuclear cell (PBMC) subsets. Patients with relapsing-remitting multiple sclerosis (RRMS) have an increased frequency of IL-11
Volume
120
Issue
26
First Page
2221007120
Last Page
2221007120
ISSN
1091-6490
Published In/Presented At
Seyedsadr, M., Wang, Y., Elzoheiry, M., Shree Gopal, S., Jang, S., Duran, G., Chervoneva, I., Kasimoglou, E., Wrobel, J. A., Hwang, D., Garifallou, J., Zhang, X., Khan, T. H., Lorenz, U., Su, M., Ting, J. P., Broux, B., Rostami, A., Miskin, D., & Markovic-Plese, S. (2023). IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system. Proceedings of the National Academy of Sciences of the United States of America, 120(26), e2221007120. https://doi.org/10.1073/pnas.2221007120
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
37339207
Department(s)
Administration and Leadership
Document Type
Article