Mouse monocytes express CD127 by immune cells, not LPS.

Authors

• Reza Yazdani
• Mozhde Askari
• Amir Moghadam Ahmadi
• Gholamreza Azizi
• Bogoljub Ciric
• Alexandra Boehm
• Guang-Xian Zhang
• Abdolmohamad Rostami

Publication/Presentation Date

1-1-2024

Abstract

The essential role of interleukin 7 (IL-7) signaling via its receptor (IL-7Rα; CD127) in T cell development and function has been well documented. However, CD127 expression and function in myeloid cells, including monocytes, are less clear, especially in mice. In the present study we report an inducible CD127 expression in mouse monocytes/macrophages. This induction is dependent on the presence of other immune cells, highlighting that regulation of CD127 expression on monocytes differs in mice and humans. We demonstrate that CD127 is functional, as IL-7 downregulated its expression. We also saw decreased CD127 expression during inflammation

Volume

15

First Page

1356004

Last Page

1356004

ISSN

1664-3224

Published In/Presented At

Yazdani, R., Askari, M., Ahmadi, A. M., Azizi, G., Ciric, B., Boehm, A., Zhang, G. X., & Rostami, A. (2024). Mouse monocytes express CD127 by immune cells, not LPS. Frontiers in immunology, 15, 1356004. https://doi.org/10.3389/fimmu.2024.1356004

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

39328413

Department(s)

Administration and Leadership

Document Type

Article