IL-7Rα on CD4

Authors

• Gholamreza Azizi
• Bram Van den Broek
• Larissa Lumi Watanabe Ishikawa
• Hamed Naziri
• Reza Yazdani
• Guang-Xian Zhang
• Bogoljub Ciric
• Abdolmohamad Rostami

Publication/Presentation Date

10-8-2024

Abstract

BACKGROUND: The IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of naive CD4

METHODS: We generated Il7ra

RESULTS: Loss of IL-7Rα from the surface of CD4

CONCLUSION: Our study demonstrates that IL-7Rα on peripheral CD4

Volume

21

Issue

1

First Page

253

Last Page

253

ISSN

1742-2094

Published In/Presented At

Azizi, G., Van den Broek, B., Ishikawa, L. L. W., Naziri, H., Yazdani, R., Zhang, G. X., Ciric, B., & Rostami, A. (2024). IL-7Rα on CD4+ T cells is required for their survival and the pathogenesis of experimental autoimmune encephalomyelitis. Journal of neuroinflammation, 21(1), 253. https://doi.org/10.1186/s12974-024-03224-2

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

39380064

Department(s)

Administration and Leadership

Document Type

Article