GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice.
Publication/Presentation Date
1-1-2025
Abstract
INTRODUCTION: GM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated. Our goal was to advance this topic using novel GM-CSF reporter/fate reporter transgenic mice.
METHODS: We tracked ongoing and past GM-CSF expression in various immune cells from multiple organs, in steady-state and autoimmune inflammation of the central nervous system (CNS).
RESULTS: The GM-CSF expression patterns varied by cell type and organ, with CD4
DISCUSSION: These findings identified distinct GM-CSF cellular sources across organs, highlighting the transient nature of GM-CSF expression and the correlation between its expression and the overall phenotype of effector memory CD4
Volume
16
First Page
1617074
Last Page
1617074
ISSN
1664-3224
Published In/Presented At
Azizi, G., Rasouli, J., Naziri, H., Gonzalez, M. V., Garifallou, J., Zhang, G. X., Ciric, B., & Rostami, A. (2025). GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice. Frontiers in immunology, 16, 1617074. https://doi.org/10.3389/fimmu.2025.1617074
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
40904462
Department(s)
Administration and Leadership
Document Type
Article