The application of reverse genetics technology in the study of rabies virus (RV) pathogenesis and for the development of novel RV vaccines.
Publication/Presentation Date
2-1-2005
Abstract
Rabies is a central nervous system (CNS) disease that is almost invariably fatal. Neurotropism, neuroinvasiveness, and transsynaptic spread are the main features that determine the pathogenesis of rabies. Recent advances in rabies virus (RV) research, which made direct genetic manipulations of the RV genome possible, greatly improved the understanding of the role of different viral and host cell factors in the pathogenesis of rabies. Here the authors discuss molecular mechanisms associated with rabies RV infection and its spread to the CNS.
Volume
11
Issue
1
First Page
76
Last Page
81
ISSN
1355-0284
Published In/Presented At
Schnell, M. J., Tan, G. S., & Dietzschold, B. (2005). The application of reverse genetics technology in the study of rabies virus (RV) pathogenesis and for the development of novel RV vaccines. Journal of neurovirology, 11(1), 76–81. https://doi.org/10.1080/13550280590900436
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15804964
Department(s)
Administration and Leadership
Document Type
Article