The cell biology of rabies virus: using stealth to reach the brain.
Publication/Presentation Date
1-1-2010
Abstract
Rabies virus, the prototypical neurotropic virus, causes one of the most lethal zoonotic diseases. According to official estimates, over 55,000 people die of the disease annually, but this is probably a severe underestimation. A combination of virulence factors enables the virus to enter neurons at peripheral sites and travel through the spinal cord to the brain of the infected host, where it often induces aggression that facilitates the transfer of the virus to a new host. This Review summarizes the current knowledge of the replication cycle of rabies virus and virus- host cell interactions, both of which are fundamental elements in our quest to understand the life cycle of rabies virus and the pathogenesis of rabies.
Volume
8
Issue
1
First Page
51
Last Page
61
ISSN
1740-1534
Published In/Presented At
Schnell, M. J., McGettigan, J. P., Wirblich, C., & Papaneri, A. (2010). The cell biology of rabies virus: using stealth to reach the brain. Nature reviews. Microbiology, 8(1), 51–61. https://doi.org/10.1038/nrmicro2260
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19946287
Department(s)
Administration and Leadership
Document Type
Article