Interferon response and viral evasion by members of the family rhabdoviridae.
Publication/Presentation Date
12-1-2009
Abstract
Like many animal viruses, those of the Rhabdoviridae family, are able to antagonize the type I interferon response and cause disease in mammalian hosts. Though these negative-stranded RNA viruses are very simple and code for as few as five proteins, they have been seen to completely abrogate the type I interferon response early in infection. In this review, we will discuss the viral organization and type I interferon evasion of rhabdoviruses, focusing on vesicular stomatitis virus (VSV) and rabies virus (RABV). Despite their structural similarities, VSV and RABV have completely different mechanisms by which they avert the host immune response. VSV relies on the matrix protein to interfere with host gene transcription and nuclear export of anti-viral mRNAs. Alternatively, RABV uses its phosphoprotein to interfere with IRF-3 phosphorylation and STAT1 signaling. Understanding the virus-cell interactions and viral proteins necessary to evade the immune response is important in developing effective vaccines and therapeutics for this viral family.
Volume
1
Issue
3
First Page
832
Last Page
851
ISSN
1999-4915
Published In/Presented At
Faul, E. J., Lyles, D. S., & Schnell, M. J. (2009). Interferon response and viral evasion by members of the family rhabdoviridae. Viruses, 1(3), 832–851. https://doi.org/10.3390/v1030832
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
21994572
Department(s)
Administration and Leadership
Document Type
Article