Rabies virus as a research tool and viral vaccine vector.
Publication/Presentation Date
1-1-2011
Abstract
Until recently, single-stranded negative sense RNA viruses (ssNSVs) were one of only a few important human viral pathogens, which could not be created from cDNA. The inability to manipulate their genomes hindered their detailed genetic analysis. A key paper from Conzelmann's laboratory in 1994 changed this with the publication of a method to recover rabies virus (RABV) from cDNA. This discovery not only dramatically changed the broader field of ssNSV biology but also opened a whole new avenue for studying RABV pathogenicity, developing novel RABV vaccines as well a new generation of RABV-based vaccine vectors, and creating research tools important in neuroscience such as neuronal tracing.
Volume
79
First Page
139
Last Page
164
ISSN
1557-8399
Published In/Presented At
Gomme, E. A., Wanjalla, C. N., Wirblich, C., & Schnell, M. J. (2011). Rabies virus as a research tool and viral vaccine vector. Advances in virus research, 79, 139–164. https://doi.org/10.1016/B978-0-12-387040-7.00009-3
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
21601047
Department(s)
Administration and Leadership
Document Type
Article